Fig. 12From: Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapyReproduced with permission from Ref [16], copyright © 2020, Royal Society of Chemistry. B Antitumor effect of Cu-PPT nanoparticles combined with immune checkpoint inhibitors. Reproduced with permission from Ref [116], copyright © 2020, American Chemical Society. C1 Mn is essential for immune responses against tumors. Mn2+ stimulates CD8+ T cells activation and promotes DCs maturation and antigen presentation. C2 Mn2+ mediated cGAS-STING pathway to activate tumor immunity. C3 Mn2+ boosts antitumor immunotherapy in mice. Reproduced with permission from Ref [41], copyright Copyright © 2020, Springer NatureMetal-based nanoparticles mediate immune activation. A Schematic illustration of the FePt/BP–PEI–FA NCs enhanced immunotherapy.Back to article page