Fig. 13
From: Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy
Reproduced with permission from Ref [56], copyright © 2019 American Chemical Society. B Lactate oxidase mediated immune activation. B1 Schematic illustration of the intra/extracellular lactic acid exhaustion process of PMLR nanosystem. B2 Tumor growth curves and survival curves of the mice with different treatments. B3 PMLR nanosystem induces tumor immunity by regulating the activity and number of various immune cells. Reproduced with permission from Ref [18], copyright © 2019 WILEY–VCH
Oxidases can relieve the immunosuppression of TME in many ways. A Glucose oxidase mediated immune activation. A1 Schematic illustration of anti-tumor immune response and enhanced anti-PD-1 immunotherapy induced by CMSN-GOx. A2 Tumor volume and survival curves in the mice after different treatments. A3 CMSN-GOx nanoparticles can promote immune activation.