Fig. 2
From: Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy
Reproduced with permission from Ref [34], copyright © 2018 American Chemical Society. B1 Formation of CP nanodots for H2O2 self-supplying CDT. B2 Flow cytometry analysis of apoptosis in U87MG cells treated with CP nanodots for 12 h and CDT potency of CP nanodots after 24 h of incubation. B3 Biodistribution of Cu in major organs and tumor of U87MG tumor-bearing mice at 24 h post i.v. injection with CP nanodots and changes in body weight of mice and tumor volume during different treatments. Reproduced with permission from Ref [36], copyright © 2019 American Chemical Society
Copper element mediates Fenton reaction to trigger CDT. A1 Schematic of the Cu-Cys NPs synthetic process and the copper-containing nanoformulation mediated CDT. A2 GSH/GSSG ratio in MCF-7R cells before and after treatment with 100 μg/mL of Cu-Cys NPs. A3 Changes in body weight of mice and tumor volume during different treatments.