Fig. 5
From: Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy
Reproduced with permission from Ref [73], copyright © 2020, American Chemical Society. B1 Illustration of lactate-depletion-enabled TME adjustment and combinational cancer treatment strategy. B2 Tumor growth curves of mice after different treatments. And lactate concentration in 4T1 tumors at 48 h post-injections. B3 Numbers of blood vessels/field and percentages of VEGF-stained area were analyzed in tumor sections. Reproduced with permission from Ref [50], copyright © 2020 WILEY–VCH
Lactate oxidase-mediated starvation therapy. A1 Schematic diagram of tumor-targeted CPGL micelles as the combination of starving and catalytic therapy basing on the generation of highly toxic ▪OH. A2 In vitro cytotoxicity of B16 cells after treated with CPGL micelles (0–0.9 μg/mL) for 24 h under different conditions (pH 7.4 and pH 6.0). A3 Monitoring body weight of mice every 2 days. And tumor volumes of B16 bearing mice after injections intravenously. The yellow arrow showed the injection time.