Fig. 2

Hemin-MSC-EXO treatment improved cardiac function in mice following infarction. A Representative echocardiographic images were taken 1 day and 28 days after MI in mice that received PBS, MSC-EXO or Hemin-MSC-EXO treatment or sham mice. B The LVEF and LVFS were calculated at baseline (before MI), 1 and 28 days in sham or mice with MI that received PBS, MSC-EXO or Hemin-MSC-EXO treatment. C Representative images of Masson’s trichrome staining of heart sections from sham or mice with MI that received PBS, MSC-EXO or Hemin-MSC-EXO treatment. Red, myocardium; blue, scarred fibrosis. D Quantitative analysis of infarct size in control or mice with MI that received injections of PBS, MSC-EXO or Hemin-MSC-EXO treatment. Data are expressed as mean ± SD. n = 6 mice for each group, ***p < 0.001