Fig. 10
From: Celastrol-based nanomedicine promotes corneal allograft survival
CPNM inhibited TLR4/MyD88/NF-κB P65 signal pathway in M1 macrophages. A The expressions and B statistical analysis of relative protein levels of TLR4, MyD88, IκBα, NF-κB P65 and TRIF in M1 Mϕ detected by WB after pretreating with CPNM for 12 h at the indicated concentrations, *P < 0.05 and **P < 0.01. C Immunofluorescence showed that CPNM inhibited TLR4/NF-κB P65 pathway in M1 macrophage. The expressions of TLR4, p IκBα and p NF-κB P65 significantly decreased in CPNM group. There was no significant difference in the expression of TRIF