Fig. 8
From: Celastrol-based nanomedicine promotes corneal allograft survival
Celastrol downregulated the expression of TLR4 in M1 macrophages. A Peritoneal cells elicited by thioglycolic acid highly express F4/80 and iNOS in wild type mouse. B The ratio of F4/80 and dextran co-labeling cell is 97.5% + 1.59%. C The expression of TLR4 reduced notably in CPNM group in wild type M1 macrophages. D The MFI of CD80, iNOS, CD206 and Arg-1 is respectively 1617, 6371, -107 and -64. E Celastrol reduced the ratio of TLR4 from 45.2% ± 3.2 to 26.7% ± 2.3% in macrophages activated by LPS