Fig. 4

In vivo theranostic effects of DS-Ce6 photoactivation on plaque burden and inflammation. a In vivo study protocol of the IVFM-assisted photoactivation and serial imaging of the carotid plaques in the atherogenic mice. b Schematic illustration of our custom-built laser modulation system. Mode scrambling technique generates a homogeneous beam profile. c Representative serial in vivo plaque imaging at baseline and 1 week after laser irradiation in the DS-Ce6 photoactivation group. d Quantitative analysis of the plaque area, macrophage area, and pTBR before and after photoactivation. n = 7 mice, ^*P < 0.05, ^**P < 0.01. e In vivo optical imaging of the carotid plaques at baseline and 1-week follow-up in the control group administered with DS-Ce6 only. f Quantitative analysis in the DS-Ce6 only control group without laser irradiation. ^**P < 0.01. n = 5 mice. g-h Serial in vivo imaging of carotid atheroma (g), and quantitative analysis (h) in laser irradiation group without DS-Ce6 administration. n = 5 mice