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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC

Fig. 4

Anticancer efficacy of Asp8[H40-TPZ/IR780@(RBC-H) NPs in vitro. a The viability of WSU-HN6 cells treated with different concentrations of Asp8[H40-TPZ/IR780@(RBC-H)] NPs with/without laser irradiation under normoxic or b hypoxia environment. And the cells incubated without nanoparticles were utilized as the control. c The fluorescent microscopy images of live/dead staining of WSU-HN6 cells incubated with different formulations with/without laser irradiation (scale bar = 50 μm). d The apoptosis analysis by Annexin V-FITC/PI staining of WSU-HN6 cells after treated with PBS, H40-PEG loading IR780 NPs, Asp8[H40-IR780@(RBC-H)] NPs, and Asp8[H40-TPZ/IR780@(RBC-H)] NPs without and with laser irradiation. All data are exhibited as the average ± standard deviation (n=3). **p < 0.01 and *** p < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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