Fig. 3
From: Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
A Release profile of TH and TH-NP adjusted to Boltzmann Sigmoidal equation. Total amount released in 24 h expressed as % Mean ± SD (n = 3). Statistical analysis one-way ANOVA t-student test *p < 0.01, B Total amount of TH and TH-NP penetrated in 24 h in healthy and damage skin. SC: stratum corneum (tape stripping), DS: deep skin (extraction). Values represent the Mean ± SD (n = 3). Statistical analysis for each localization via one-way ANOVA Tukey's Multiple Comparison Test. Different letters inside the bars indicates significant differences between groups (*p < 0.01 and **p < 0.001), C Confocal microscopy images of pig skin R-TH-NP penetration after 24 h: I untreated skin control, II SC and hair follicle, III hair follicle cross-section