Table 2 Physicochemical stability of TH-NP stored at different temperatures (4, 25 and 37 °C) measured at 0, 1, 3, 6 and 12 months
From: Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
t (months) | Zav (nm) | PI | ZP (mV) | pH | |
|---|---|---|---|---|---|
0 | 158.8 ± 1.7 | 0.068 ± 0.027 | − 24.7 ± 1.0 | 4.20 | |
4 °C | 1 | 158.6 ± 1.8 | 0.108 ± 0.046 | − 20.1 ± 0.6 | 4.07 |
3 | 159.0 ± 2.1 | 0.101 ± 0.034 | − 17.1 ± 0.1 | 3.90 | |
6 | 168.6 ± 1.7 | 0.152 ± 0.033 | − 15.3 ± 0.1 | 3.68 | |
12 | 204.5 ± 1.3 | 0.231 ± 0.015 | − 11.1 ± 0.7 | 3.61 | |
25 °C | 1 | 162.3 ± 0.4 | 0.119 ± 0.015 | − 19.1 ± 0.1 | 3.91 |
3 | 182.3 ± 1.4 | 0.145 ± 0.020 | − 10.3 ± 0.2 | 3.64 | |
37 °C | 1 | 177.4 ± 1.2 | 0.128 ± 0.012 | − 15.3 ± 0.6 | 3.32 |
3 | 216.4 ± 2.8 | 0.205 ± 0.001 | − 8.56 ± 0.3 | 2.95 |