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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

Fig. 3

In vitro antitumor effect on colorectal CT26 cells of TIR@siRNA mediated gene enhanced nuclear-targeting SDT. A Cytotoxicities on CT26 cells after 24 h treatments of free IR780, TIR and TIR@siRNA with/without US irradiation. B The LIVE/DEAD analysis by confocal microscope and C the cell apoptosis analysis by flow cytometry of CT26 cells at 24 h after various treatments (Q1: dead cells; Q2: late apoptotic cells; Q3: early apoptotic cells; Q4: live cells). D Confocal images of CT26 cells stained with DAPI and antibodies against γ-H2AX after various treatments. US irradiation was carried out at a power density of 1.0 W/cm2 for 5 min with 50% duty cycle

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Journal of Nanobiotechnology

ISSN: 1477-3155

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