Fig. 5

In vivo tumor retention and tissue distribution of TIR@siRNA in CT26 tumor bearing mice. A In vivo fluorescence images of the mice and B the change curves of mean fluorescence intensity of tumors at 0 h, 6 h, 24 and 48 h after intratumoral injection of normal saline, free IR780, TIR and TIR@siRNA. C Fluorescence images and D mean fluorescence intensity changes of diluted whole blood derived from the mice at the corresponding time points. Fluorescence images (E) and mean fluorescence intensity (F) of ex vivo tumor tissues and major organs (G) of the mice at 48 h post administration. All data are presented as the mean± SD (n = 3). *P < 0.05 and **P < 0.01 for the comparisons between two treatment groups