Fig. 7

Anticancer effects of TIR@siRNA mediated gene augmented nuclear-targeting SDT in CT26 tumor-bearing mice. A Tumor growth curves during treatments of normal saline, US irradiation, TIR@siRNA and free IR780, TIR, TIR@siRNA combined with US irradiation (+U). Photos (B) and weights (C) of the tumors and dissected from the mice at the end of various treatments. D Body weights changes of the mice during various treatments. E Microscope images of tumor sections with H&E staining, TUNEL staining and immunohistochemical staining of Ki67. In above experiments, the doses of IR780 and Nrf2-siRNA were 2.0 mg/kg and 0.5 mg/kg, respectively. All data are presented as the mean± SD (n = 5). ***P < 0.005 as compared to the control and ^#P < 0.05, ^##P < 0.01 for the comparison between two treatment groups