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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Chemo-photodynamic therapy with light-triggered disassembly of theranostic nanoplatform in combination with checkpoint blockade for immunotherapy of hepatocellular carcinoma

Fig. 4

ROS generation, intracellular PTX release and synergistic chemo-PDT in vitro. A Detection of the intracellular ROS generation induced by TB-mediated PDT in Hep 1–6 and Hep G2 cells. Scale bar: 20 μm. B Immunofluorescent staining of acetylated α-tubulin in Hep 1–6 and Hep G2 cells after treatment with PBS (negative control), TB@RTK, TB@RTK + light, TB/PTX@RTK, TB/PTX@RTK + light. Scale bar: 20 μm. C Flow cytometric analysis of cell apoptosis and necrosis in Hep 1–6 and Hep G2 cells after treatment with PBS (negative control), TB@RTK, TB@RTK + light, TB/PTX@RTK, TB/PTX@RTK + light. D Cell viability following treatment with PBS (negative control), TB@RTK, TB@RTK + light, TB/PTX@RTK, TB/PTX@RTK + light. E Cell viability after treatment with different concentration of TB/PTX@RTK micelles or time of light irradiation

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Journal of Nanobiotechnology

ISSN: 1477-3155

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