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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Chemo-photodynamic therapy with light-triggered disassembly of theranostic nanoplatform in combination with checkpoint blockade for immunotherapy of hepatocellular carcinoma

Fig. 6

ICD induction, immune activation and adaptive immune resistance of TB/PTX@RTK-mediated chemo-PDT (G1: PBS; G2: TB@RTK; G3: TB@RTK + L; G4: TB/PTX@RTK; and G5: TB/PTX@RTK + L). A Immunofluorescence imaging of CRT expression on the membrane surface of Hep 1–6 cells after different treatments. DiI indicates the cytomembrane. Scale bars: 10 μm. Extracellular ATP (B) and HMGB1 (C) levels after different treatments. *P < 0.05, **P < 0.01, ***P < 0.001. (D–I) Representative plots of flow cytometric analysis and statistical analysis of mature BMDCs (CD11c+CD80+CD86+; D and E), CTLs (CD45+CD3+CD8+; F and G) and Treg cells (CD3+CD4+Foxp3+; H and I) in the tumors. J Immunofluorescence imaging of membrane PD-L1 proteins on Hep 1–6 cells after different treatments. DiI indicates the cytomembrane. Scale bars: 10 μm

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