Fig. 6
From: One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
In vivo evaluation of biodistribution and therapeutic efficacy. a Representative IVIS fluorescence images of mice before and after intravenous injection of free DiR or DiR/ BTNPs at different time points (n = 3). b Ex vivo fluorescence imaging and (c) fluorescence radiance of tumor (Tu), heart (He), liver (Li), spleen (Sp), lung (Lu), and kidney (Ki) 24 h post-administrations (n = 3). Tumor volumes (d), photographs of the excised tumors after treatments (e), tumor weights (f) of mice over the 14-day treatments (n = 4). All the light irradiations were performed 24 h post-injection with a 635 nm laser (200 mW/cm2, 10 min). g H&E and TUNEL staining of the tumor slices of each group. Scale bar: 200 μm (H&E) and 50 μm (TUNEL). h Body weights of mice over the 14-day treatments (n = 4)