Fig. 4
From: RETRACTED ARTICLE: A stepwise-targeting strategy for the treatment of cerebral ischemic stroke
Biodistribution of TGN/SHp/TPP-MLT micelles. A Representative fluorescence images of bEnd.3 cells incubated with TGN/SHp/cy3 micelles for for 0.5 and 2.0 h, TGN/cy3 micelles, SHp/cy3 micelles, cy3 micelles and free cy3 as control.Scale bar, 50 µm. B The transport ratios (%) of TGN/SHp/cy3 micelles across BBB model, TGN/cy3 micelles, SHp/cy3 micelles, cy3 micelles and free cy3 as control (n = 6, P > 0.05). C Representative fluorescence images of PC-12 cells incubated with TGN/SHp/cy3 micelles for for 0.5 and 2.0 h, TGN/cy3 micelles, SHp/cy3 micelles, cy3 micelles and free cy3 as control.Scale bar, 20 µm. D Representative fluorescent images of brain tissue in CIS mice treated with TGN/SHp/Dir micelles, Dir micelles as control. E The tissue distribution of TGN/SHp/TPP-MLT micelles in CIS mice at 0.5, 2.0 and 8.0 h after intravenous administration at a dose of 5 mg/kg TPP-MLT, free TPP-MLT and TPP-MLT micelles (n = 6, *P < 0.05). F TPP-MLT contents in ischemic and normal brain sides (n = 6, *P < 0.05)