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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Multifaceted glycoadjuvant@AuNPs inhibits tumor metastasis through promoting T cell activation and remodeling tumor microenvironment

Fig. 4

gCpG promotes antigen-specific CD8+ T cells response. a Tetramer staining of OVA–specific CD8+ T cells in TILs. Proliferations of CD4+ (b) or CD8+ (c) T cells isolated from spleen were determined using CCK8 cell counting kits. The stimulation index (SI) is calculated as the ratio of the proliferation of cells received OVA-specific stimulation to cells without OVA-specific stimulation in the same group. Cytotoxicity assay of splenic CD8+ T cells (d) and other population without CD8+ T cells (e) from the tumor-bearing mice against B16-OVA tumor cells. The specific killings were determined using CytoTox 96 nonradioactive cytotoxicity assay. *p < 0.05 and **p < 0.01, ***p < 0.001 and ****p < 0.0001

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