Fig. 7
Synergetic enhancement of therapeutic efficacy by gCpG combined with anti-PD1 antibody. PD1 expression (MFI) on tumor infiltrating CD8+ (a) and CD8+ (b) T cells. c Metastatic nodules of 2 × 106 B16-OVA mice treated with PBS, CpG + OVA or gCpG + OVA on day 17. On days 5 and 10, 200 μg α-PD1 was administered i.p. The data shown are the representative of three experiments. *p < 0.05 and **p < 0.01, ***p < 0.001 and ****p < 0.0001