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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy

Fig. 5

Cilengitide encapsulated in a doxorubicin (DOX)-loaded thermosensitive liposome via a MT1-MMP-cleavable peptide improves tumor blood perfusion and drug delivery in pancreatic cancer. Cilengitide is released through MT1-MMP cleavage on tumor endothelial cells (ECs), promoting EC migration and angiogenesis. MT1-MMP, membrane type 1-matrix metalloproteinase; MC, MT1-MMP-activated cilengitide. Reprinted by permission from [79]

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Journal of Nanobiotechnology

ISSN: 1477-3155

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