Fig. 7

Therapeutic efficacy of various nanocomposites in vivo. A Experimental procedure designed for nanocomposite therapy. B Body weight curve of mice after intratumoral injection with various therapeutic nanocomposites following the experimental scheme. C Digital photographs of mice and dissected tumors. D Time-dependent tumor growth curves (n = 5, mean ± SD). E Tumor weight after 15 days of treatment. F P-gp immunohistochemical staining and TUNEL staining for analysis of pathological changes. Scale bar = 100 μm. G H&E staining and Ki-67 immunohistochemical staining for cellular proliferation analysis in tumor tissue after 15 days of treatment. Scale bar = 500 µm. NP, nanoparticle; SD, standard deviation; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; P-gp, P-glycoprotein; H&E, hematoxylin and eosin