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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis

Fig. 4

Analgesic and anti-inflammatory effects of ST36 nanocomposite hydrogel. a The schematic diagram of experiment procedure. b Mechanical allodynia (paw withdrawal latency in grams) among the different groups. c Thermal hyperalgesia (paw withdrawal threshold in seconds) among four groups. d Photographs of representative mice hand paws among the six groups. (Normal: healthy mice treated with saline, Model: AIA mice treated with saline, G1: ST36 TP-CCPA-solution, G2: ST36 TP-CCPA-Gel, G3: ST36 TP@HSA NPs-CCPA-Gel, G4: Non-acupoint TP@HSA NPs-CCPA-Gel) e–g Hind paw thickness, volume, and arthritis scores changes of the mice. Data (means ± SD) shown are pooled from two independent experiments with similar results. (n = 6, *p < 0.05, **p < 0.01, and ***p < 0.001)

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