Fig. 6

Immunohistochemistry analysis of articular tissues. a immunohistochemical image of cartilage and synovium in different groups. Black arrows: positive staining. Scale bar:100 μm. b Quantification of the IL-1β, IL-6 and TNF-α production in the tissues treated with different samples based on the immunohistochemical results. G1: ST36 TP-CCPA-solution, G2: ST36 TP-CCPA-Gel, G3: ST36 TP@HSA NPs-CCPA-Gel, G4: Non-acupoint TP@HSA NPs-CCPA-Gel. Data are reported as mean ± SD (n = 3), *p < 0.05, **p < 0.01, ***p < 0.001