Fig. 3
As@ZIF-8 NPs inhibited the proliferation and promoted the apoptosis of sublethally heated cells in vitro. A Viability of Hep3B, SMMC7721, and L02 cells after incubation with the indicated concentrations of free ATO or As@ZIF-8 NPs for 48 h (n = 3). B IC50 of Hep3B, SMMC7721, and L02 cells after treatment with ATO or As@ZIF-8 NPs (n = 3). C Quantitative analysis chart of colony formation of sublethally heated Hep3B and SMMC7721 cells after incubation with free ATO, As@ZIF-8 NPs or ZIF-8 NPs for 24 h (n = 3). D, E Living/dead cell double staining of sublethally heated Hep3B (D) and SMMC7721 cells (E) after the indicated treatment. Scale bar, 1000 µm. F Quantitative analysis chart of apoptosis rates of sublethally heated Hep3B and SMMC7721 cells after incubation with free ATO, As@ZIF-8 NPs or ZIF-8 NPs (n = 3). G Viability of Hep3B, SMMC7721, MHCC97H, and L02 cells after incubation with the indicated concentrations of ZIF-8 NPs for 48 h (n = 3). (*P < 0.05; **P < 0.01)