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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Augmented EPR effect post IRFA to enhance the therapeutic efficacy of arsenic loaded ZIF-8 nanoparticles on residual HCC progression

Fig. 4

As@ZIF-8 NPs inhibited the invasion, migration and EMT of sublethally heated cells in vitro. A, B Wound healing assay of sublethally heated Hep3B (A) and SMMC7721 cells (B) after incubation with free ATO, As@ZIF-8 NPs and ZIF-8 NPs for 24 h. Scale bar, 800 µm. C–E Representative images of the migration and invasion of sublethally heated Hep3B (C) and SMMC7721 cells (D) after the indicated treatment and the related quantitative analysis chart (E). Scale bar, 1000 µm. F Protein expression of EMT markers N-cadherin, vimentin and E-cadherin in Hep3B and SMMC7721 cells after the indicated treatment. (ns, no statistical difference; *P < 0.05)

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