Fig. 6

As@ZIF-8 NPs inhibited the growth and metastasis of residual tumors in vivo. A Schematic diagram of subcutaneous tumor treatment. B Tumor growth curve of the mice after different treatments (n = 5). C Tumor weight obtained from the mice receiving different treatments (n = 5). D Photographs of excised tumors 21 days after different treatments were administered. E, F HE staining (E) of lung metastasis area after different treatments and quantification (n = 5) (F). Scale bar, 500 µm. G, H Immunohistochemical staining (H) of N-cadherin and E-cadherin in tumor tissues 21 days after different treatments were administered and quantification of the H-score (n = 5) (G). H-score, histochemistry score. Scale bar, 20 µm (*P < 0.05; **P < 0.01; ***P < 0.001)