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Table 1 The main pharmacokinetic parameters of Taxotere® and FA-BSA-PEG/MoOx + DTX after intravenous administration

From: A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases

Parameters

Taxotere®

Nanosheet

AUC(0-t) (mg/L*h)

3.29 ± 0.24

10.68 ± 0.58***

AUC(0-∞) (mg/L*h)

4.13 ± 0.06

15.28 ± 1.66**

MRT(0-t) (h)

1.46 ± 0.14

7.38 ± 0.32***

MRT(0-∞) (h)

4.65 ± 0.83

31.01 ± 6.71*

t1/2z (h)

5.72 ± 0.78

35.06 ± 7.50*

CLz (L/h/kg)

2.42 ± 0.04

0.66 ± 0.08***

Cmax (mg/L)

8.37 ± 1.33

17.62 ± 2.06**

  1. Asterisks (*) denote statistical significance of nanosheet vs. commercial Taxotere® (*p < 0.05, **p < 0.01, ***p < 0.001)
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Journal of Nanobiotechnology

ISSN: 1477-3155

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