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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model

Fig. 2

NanoString analysis of immune-gene expression in the secondary tumors. A Heatmap of the activities of various immune pathways. B Changes in gene expression in innate pathway, adaptive pathway, T cell and NK cell function in the NBTXR3  +  HDXRT  +  LDXRT  +  ICIs group relative to the NBTXR3  +  HDXRT  +  ICIs group and the HDXRT  +  LDXRT + ICIs group. C Relative scores for total tumor-infiltrating lymphocytes (TILs), dendritic cells, CD8 T cells, and regulatory T (Treg) cells. Data are expressed as means  ±  standard error of the mean (SEM). P  < 0.05 was considered statistically significant. *P  < 0.05, **P  < 0.01, ***P  < 0.001, NS not significant. HDXRT high-dose radiotherapy; LDXRT low-dose radiotherapy; ICIs immune checkpoint inhibitors

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