Fig. 4

NBTXR3 increases the number of overlapping TCRβ receptors. A Representative Circos plots displaying the pairings of V-J gene families of the TCRβ and TCRα repertoires from all four treatment groups. Each stem connecting V and J gene pairs represent a unique CDR3 clonotype, and stem thickness is proportional to the CDR3 frequency. The lengths of the arcs are proportional to the gene family frequencies within each mouse repertoire. B Comparisons of overlapping, F-measure-normalized CDR3β frequencies within and between all four treatment groups. C Comparisons of overlapping, F-measure-normalized CDR3α frequencies within and between all four treatment groups Error bars represent means with standard deviation. P  < 0.05 from Mann–Whitney U tests was considered statistically significant. *P  < 0.05, **P  < 0.01, ***P  < 0.001, ****P  < 0.0001, NS not significant. HDXRT high-dose radiotherapy; LDXRT low-dose radiotherapy; ICIs immune checkpoint inhibitors