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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Nanofactory for metabolic and chemodynamic therapy: pro-tumor lactate trapping and anti-tumor ROS transition

Fig. 3

Intracellular behaviors of PLNPCu. a The cytotoxicity of PLNPCu and LOX against 4T1 cells (n = 5). b The flow cytometry analysis of cellular uptake of different agents (LOX@FITC, LNPCu@FITC, PLNPCu@FITC pH = 7.4 and PLNPCu@FITC pH = 6.5) after 3 h of incubation with 4T1 cells. (n = 3) c The lactate consumption analysis in 4T1 cell supernatant after treatment with PLNPCu. (n = 3) d Fluorescent microscopy image of intracellular ROS generation. Scale bars, 100 μm. e, f The flow cytometry analysis of ROS generation after treatment with PBS, LOX, PLNPCu pH = 6.5 and PLNPCu pH = 7.4. Results were expressed as mean ± SD. The significant difference was calculated via one-way ANOVA analysis (b, c, f). (NS represented not significant, *p < 0.05, **p < 0.01, ***p < 0.001)

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