Fig. 3

A Pharmacokinetic behavior of FeS₂, RF, and CF in mice following i.v. administration at doses of 2.5 mg Fe/kg. Data are presented as mean  ±  SD (n  = 3). B Quantitative analysis of FeS₂ biodistribution in tissues and tumors of tumor-bearing mice injected with FeS₂, RF, or CF at FeS₂ dose of 2.5 mg Fe/kg, respectively. C Change in tumor-volume curves of 4T1 tumor-bearing mice after treatments. D Changes in tumor weight following treatment. E The body weight of 4T1 tumor-bearing mice was measured every 2 days after therapy. F Following therapy, TUNEL and H&E-stained tumor slice photos of mice are shown. Significant differences among groups as calculated using the student’s t test. **P  < 0.01, ***P  < 0.005