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Table 3 EVs based intervention clinical trials

From: A systematic review on the modifications of extracellular vesicles: a revolutionized tool of nano-biotechnology

EVs Source

Condition

Drug

Administration Route

Dose Reported

Phase

Study Identifier

MSCs

Cerebrovascular disorders/stroke

miR-124

i.v

200 µg protein

1/2

NCT03384433

MSCs

Alzheimer Disease

No

Nasal drip

5 μg–20 μg

1/2

NCT04388982

MSCs

Periodontitis

No

Local

Not reported

early 1

NCT04270006

MSCs

Neuralgia

No

i.v. epineurally

45 mg, 15 mg

n/a

NCT04202783

MSCs

Depression

No

i.v

21 million cells

n/a

NCT04202770

MSCs

Diabetes Mellitus Type 1

No

i.v

1.2 × 1010–1.51 × 1010 particles/kg

2/3

NCT02138331

MSCs

Chronic Ulcer

No

Topical

Not reported

1

NCT04134676

Plasma

Ulcer

No

Topical

Not reported

Early 1

NCT02565264

MSC

Dystrophic Epidermolysis Bullosa

No

Topical

Not reported

1/2

NCT04173650

MSCs

Multiple Organ Failure

No

i.v

150 mg once a day for 14 times

n/a

NCT04356300

MSCs

Healthy

No

Inhalation

2 × 108–20 × 108 particles/3 ml

1

NCT04313647

Plant

Colon Cancer

Curcumin

Oral

Not reported

1

NCT01294072

Plant

Polycystic Ovary Syndrome

No

Oral

Not reported

n/a

NCT03493984

Grape

Head and Neck Cancer Oral Mucositis

No

Oral

Not reported

1

NCT01668849

DCs

Non Small Cell Lung Cancer

MHC class I- class II- cancer antigens

i.v

53–2422 μg protein/injection

2

NCT01159288

MSCs

Pancreatic Adenocarcinoma

KRAS G12D siRNA

i.v

Days 1, 4, and 10 (dose not reported)

1

NCT03608631

MSCs

SARS-CoV-2 pneumonia

No

Inhalation

2 × 108 particles/3 mL

1

NCT04276987

MSCs

SARS-CoV-2 pneumonia

No

Inhalation

0.5 × 1010–2 × 1010 particles/3 ml

1/2

NCT04491240

Bone marrow

SARS-CoV-2 pneumonia

No

i.v

Not reported

2

NCT04493242

Human amniotic fluid

SARS-CoV-2 pneumonia

No

i.v

2 × 1010–5 × 1010 particles

1/2

NCT04384445

MSCs

Dry Eye

No

Eye drop

10 µg/drop

1/2

NCT04213248

MSCs

Macular Holes

No

Drop

50 μg or 20 μg

Early 1

NCT03437759

  1. (Adapted from Ref No. [66]) under the Creative Commons Attribution License 4.0