EVs Source | Condition | Drug | Administration Route | Dose Reported | Phase | Study Identifier |
---|---|---|---|---|---|---|
MSCs | Cerebrovascular disorders/stroke | miR-124 | i.v | 200 µg protein | 1/2 | NCT03384433 |
MSCs | Alzheimer Disease | No | Nasal drip | 5 μg–20 μg | 1/2 | NCT04388982 |
MSCs | Periodontitis | No | Local | Not reported | early 1 | NCT04270006 |
MSCs | Neuralgia | No | i.v. epineurally | 45Â mg, 15Â mg | n/a | NCT04202783 |
MSCs | Depression | No | i.v | 21 million cells | n/a | NCT04202770 |
MSCs | Diabetes Mellitus Type 1 | No | i.v | 1.2 × 1010–1.51 × 1010 particles/kg | 2/3 | NCT02138331 |
MSCs | Chronic Ulcer | No | Topical | Not reported | 1 | NCT04134676 |
Plasma | Ulcer | No | Topical | Not reported | Early 1 | NCT02565264 |
MSC | Dystrophic Epidermolysis Bullosa | No | Topical | Not reported | 1/2 | NCT04173650 |
MSCs | Multiple Organ Failure | No | i.v | 150Â mg once a day for 14 times | n/a | NCT04356300 |
MSCs | Healthy | No | Inhalation | 2 × 108–20 × 108 particles/3 ml | 1 | NCT04313647 |
Plant | Colon Cancer | Curcumin | Oral | Not reported | 1 | NCT01294072 |
Plant | Polycystic Ovary Syndrome | No | Oral | Not reported | n/a | NCT03493984 |
Grape | Head and Neck Cancer Oral Mucositis | No | Oral | Not reported | 1 | NCT01668849 |
DCs | Non Small Cell Lung Cancer | MHC class I- class II- cancer antigens | i.v | 53–2422 μg protein/injection | 2 | NCT01159288 |
MSCs | Pancreatic Adenocarcinoma | KRAS G12D siRNA | i.v | Days 1, 4, and 10 (dose not reported) | 1 | NCT03608631 |
MSCs | SARS-CoV-2 pneumonia | No | Inhalation | 2 × 108 particles/3 mL | 1 | NCT04276987 |
MSCs | SARS-CoV-2 pneumonia | No | Inhalation | 0.5 × 1010–2 × 1010 particles/3 ml | 1/2 | NCT04491240 |
Bone marrow | SARS-CoV-2 pneumonia | No | i.v | Not reported | 2 | NCT04493242 |
Human amniotic fluid | SARS-CoV-2 pneumonia | No | i.v | 2 × 1010–5 × 1010 particles | 1/2 | NCT04384445 |
MSCs | Dry Eye | No | Eye drop | 10 µg/drop | 1/2 | NCT04213248 |
MSCs | Macular Holes | No | Drop | 50 μg or 20 μg | Early 1 | NCT03437759 |