Fig. 1
From: Sonosensitive capsules for brain thrombolysis increase ischemic damage in a stroke model
A Scanning electron microscope (SEM) micrograph of cores (scale bar is 500 nm). B Size histogram (dcore@rtPA: mean diameter of core@rtPA, rtPA loaded vaterite CaCO3 cores) obtained after measuring the diameter of 300 core@rtPA using ImageJ; dcore@rtPA = 580 ± 111 nm. C SEM micrograph of SC@rtPA (no gelatine) before core removal (scale bar is 500 nm). D Size histogram (dSC@rtPA: mean diameter of SC@rtPA) obtained after measuring the diameter of over 300 SC@rtPA using ImageJ; dSC@rtPA = 599 ± 60 nm. E SEM micrograph of SC@rtPA-G (gelatine) after core removal (scale bar is 500 nm). F Size histogram (dSC@rtPA-G: mean diameter of SC@rtPA-G) obtained after measuring the diameter of over 300 SC@rtPA-G using ImageJ; dSC@rtPA-G = 632 ± 65 nm. G Mean average hydrodynamic diameters and ζ-potential values for core@rtPA, SC@rtPA and SC@rtPA-G. H Transmission electron microscopy (TEM) micrograph of SC@rtPA after core removal (scale bar is 500 nm); ioNPs are distinguishable as dark dots in the polymer shell of collapsed SCs