Fig. 2

rtPA plasmatic profile of the groups of healthy animals treated with A vehicle (saline) and vehicle with ultrasound (US) administration; B rtPA (1 mg/kg as bolus), rtPA (1 mg/kg as bolus) with US and rtPAi (10 mg/kg administered 10% as bolus and 90% as infusion); C SCs@rtPA (1 mg/kg as bolus) and SCs@rtPA (1 mg/kg as bolus) with US; D SCs@rtPA-G (1 mg/kg as bolus) and SCs@rtPA-G (1 mg/kg as bolus) with US. The dotted lines represent the plasma activity of the control group treated with the vehicle. The square symbols represent the groups treated without US, while the triangles are the groups treated with US. All data are represented as mean ± SD (n = 3 per treatment group). In all data statistical analysis was assessed by a one-way ANOVA followed by post-hoc Brown-Forsythe evaluation: *(P < 0.05), **(P < 0.01), ***(P < 0.001) compared to vehicle, and, ^##(P < 0.01) compared to SC@rtPA-G at the same timepoints