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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Sonosensitive capsules for brain thrombolysis increase ischemic damage in a stroke model

Fig. 3

A Schematic representation of EB extravasation after ischemia. When the blood brain barrier (BBB) is compromised, the extravasation of EB into the parenchyma occurs. B Analysis of the BBB disruption in healthy and ischemic mice under ultrasound (US) exposure determined by EB extravasation. Amount (µg) of EB was corrected by the brain tissue weight (g). C MRI of the ischemic animals with and without (W/O) US. D Ischemic volume analysis with and without US application. All data are represented as mean ± SD (n = 5 per treatment group). In all data statistical significance was assessed by the t-test. **P < 0.01; *** P < 0.001. Each ipsilateral hemisphere was compared with its respective contralateral hemisphere

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