Fig. 4
From: Sonosensitive capsules for brain thrombolysis increase ischemic damage in a stroke model
A Murine model of thromboembolic stroke induced by the occlusion of the medial cerebral artery (MCAo) with thrombin injection. B Representation of the Cerebral Blood Flow (CBF) recording without reperfusion and C with reperfusion. Red arrows indicate the arterial occlusion induced by thrombin injection, and 35 min later the treatment administration (blue arrows): saline or vehicle (vehicle, vehicle with ultrasound), rtPA free solution (rtPA (1 mg/kg as bolus), rtPA with US (1 mg/kg as bolus), rtPAi (rtPA 10 mg/kg as bolus and infusion), SC@rtPA (1 mg/kg as bolus), SC@rtPA with US (1 mg/kg as bolus), SC@rtPA-G (1 mg/kg as bolus) and SC@rtPA-G with US (1 mg/kg as bolus). D Reperfusion rate in the different groups (n = 5 per treatment group) determined by laser Doppler monitoring. Successful reperfusion was considered when at least 40% of the basal CBF was recovered. Animals treated without ultrasound (US) are marked as W/O