Fig. 1From: Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathologyAggregation of Aβ1–42 at different temperatures. ThT kinetic assays showing the spontaneous aggregation curves and the corresponding fluorescence images of 2.5 µM (A–D), 5 µM (E–H), 10 µM (I–L) and 20 µM (M–P) Aβ1–42 over 24 h incubation at 27 °C (black), 37 °C (red) and 40 °C (blue). Note the aggregation of Aβ1–42 increases as functions of dose and temperature which reach plateaus over time as indicated by ThT fluorescence levels. The fluorescence images of different Aβ1–42 concentrations were taken following 24 h incubation at 27 °C, 37 °C and 40 °C. Rate constant of the kinetic reaction “K” at different concentrations of Aβ1–42 are shown in the inset of respective aggregation kinteic curvesBack to article page