Skip to main content
Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

Fig. 3

Attenuation of Aβ1–42 aggregation by PLGA as revealed by STEM. A STEM image showing the spherical morphology of unconjugated PLGA nanoparticles without Aβ peptide. STEM images of 10 µM Aβ1–42 following 24 h incubation in the absence (B, D, F) and presence (C, E, G) of 25 µM PLGA at 27 °C (B, C), 37 °C (D, E) and 40 °C (F, G). Note the relative decrease in the amount of Aβ fibrils at different temperatures in presence of 25 µM PLGA. STEM images showing higher magnification of Aβ1–42 samples in the absence (H) and presence (I) of 25 µM PLGA at 37 °C. Note the localization of twisted fibers in the PLGA-treated Aβ sample. PLGA nanoparticles are indicated with arrows

Back to article page