Fig. 4
Attenuation of Aβ1–42 aggregation by PLGA as revealed by AFM. AFM images in height (A) and amplitude (B) modes showing spherical morphology of unconjugated PLGA nanoparticles without Aβ peptide. AFM images in height (C, D) and amplitude (E, F) modes of 10 µM Aβ1–42 following 24 h incubation in the absence (C, E) and presence (D, F) of 25 µM PLGA at 37 °C. Note the formation and structural details of different populations of smaller aggregates such as short twist fibrils and oligomers in presence of 25 µM PLGA compared to untreated control Aβ1–42. PLGA nanoparticles are highlighed with arrows