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Table 2 CD spectroscopy data depicting α-helical and β-sheet contents following 24 h aggregation of 10 µM Aβ1–42 at different temperatures in the absence and presence of 25 µM unconjugated PLGA

From: Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

 

α-helical content (%)

β-sheet content (%)

1–42 (27 °C)

2

39

1–42 (37 °C)

2

42

1–42 (40 °C)

2.1

46

1–42 +  PLGA (27 °C)

24

32

1–42 +  PLGA (37 °C)

20

36

1–42 +  PLGA (40 °C)

18

39