Fig. 4

In vitro and in vivo targeting ability of BA/Res@NP-PBP. A Confocal images of cell uptake of NPs by Raw 264.7 cells and Colon-26 cells. The colors are as follows: DAPI, blue; FITC, green; DiL, red. Scale bar: 20 μm. B The binding of BA/Res@NP-PBP on Raw 264.7 cells and Colon-26 cells was observed by field emission scanning electron microscopy (FE-SEM). C Mice with DiR-labeled BA/Res@NP and D BA/Res@NP-PBP were imaged by in vivo imaging system (IVIS). E Histogram statistics were performed on fluorescence intensity of images (n = 5), *p < 0.05, **p < 0.01. The red arrows indicate NPs