Fig. 6

Evaluation of the sensitivity and specificity of the biosensor: A DPV curves response of the electrochemical biosensor upon the increase in target BCR/ABL fusion gene concentration (from bottom to top: 0 fM, 0.2 fM, 2 fM, 20 fM, 200 fM, 2 pM, 20 pM, 200 pM, and 2 nM, 20 nM, separately) and B the corresponding linear relationship between DPV signal and logarithmic value of target BCR/ABL fusion gene concentrations (range of concentration: 20 aM, 0.2 fM, 2 fM, 20 fM, 200 fM, 2 pM, 20 pM, 200 pM, and 2 nM, 20 nM, 200 nM, 2 uM separately). C DPV responses of the electrochemical biosensor to different oligonucleotides (20 fM): (a) BCR/ABL fusion gene (target), (b) single-base-mismatched strand (B1), (c) two-base-mismatched strand (B2), (d) noncomplementary strand (B3), and (e) blank. D Stability of the proposed biosensor. The error bars represent the standard deviation of three parallel measurements