Fig. 5
From: Recent progress in advanced biomaterials for long-acting reversible contraception
(Reprinted with permission from reference [8]. Copyright 2019 American Association for the Advancement of Science)
A Schematic representation of the design of the MNs with bubbly sponsorship and the interaction of application to fast convey MNs into the skin. B Rapid detachment of MNs patches from effervescent backing. C Representative images of skin, tissue section, and rat after MNs application and removal. D Structural changes of MNs before and after application and human skin reaction in 0–24 h. E The efficiency of penetration and detachment of the microneedles and Normalized erythema intensity of human skin in 0–24 h