Table 5 The development of solving the “burst-releasing” phenomenon of Cu2+
From: Recent progress in advanced biomaterials for long-acting reversible contraception
Materials | Bio-component | Technological breakthrough | Ref. |
|---|---|---|---|
IDM delivery system | Indomethacin | ① The initial explosion release of Cu2+ was eliminated ② The sustained release time of IDM was controlled by adjusting the number of layers of the film | [109] |
Novel Cu/PDMS nanocomposite | Nano-Cu particles | ① The distribution of Cu nanoparticles was more uniform in the PDMS matrix ② The release rate of Cu2+ became adjustable by changing the number of Cu nanoparticles | [110] |
CuT380 IUD with PLGA film | PLGA film | The occurrence of the burst release of Cu2+ was relieved by coating PLGA on the CuT380 | [111] |
Phytocompound-based electropolymeric coating | PolyCarvCu coating | It was a strong inhibitory effect on the initial release of Cu2+ | [112] |