Fig. 8
From: Quantitative hypoxia mapping using a self-calibrated activatable nanoprobe
Imaging of lymph-node metastasis. a Digital photo, in vivo fluorescence and fluorescence ratio images of tumor-associated pLN and control pLN. b Digital photo, ex vivo fluorescence and fluorescence ratio images of the excised pLNs. c GFP fluorescence image confirming the presence of metastatic 4T1-GFP cells in the tumor-associated pLN; solid arrows: GFP fluorescence tumor cells. d qPCR showing the relative expression of GFP in the control and tumor-draining pLNs of each mouse, error bar, mean \(\pm\) s.d. (n = 6). e Linear regression determined the correlation between in vivo imaging and qPCR results (R2 = 0.6365, p = 0.0572)