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Fig. 10 | Journal of Nanobiotechnology

Fig. 10

From: Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy

Fig. 10

Schematic illustration of exosomes derived from BMP2 genetically engineered MSCs promote bone regeneration. MSCs were genetically engineered by liposome mediated BMP2 gene delivery, and altered the content of secreted exosomes. This MSC-BMP2-Exo with the content derived from MSCs and up-regulated osteogenic related gene expression synergistically promoted bone regeneration. Both the liposome and exosomes rely on endosome-mediated cellular transportation, therefore, the pBMP2 delivered by liposome could be re-encapsulated in exosomes to present a safety carrier. This provide a strategy of making use of mediator cells as cellular factories to produce exosomes with designed therapeutic information

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