Fig. 3

MiR-125b is involved in exosome^Young -mediated wound healing.A Heat map of miRs differentially expressed in exosome^Old and exosome^Young. B MiR-125b expression was validated by qRT-PCR in exosome^Old and exosome^Young. ^*P < 0.05 versus exosome^Old in paired t-test (n = 6). C MiR-125b expression was validated by qRT-PCR after transfection of miR-125 mimic, or miR mimic negative control (NC) intradermally into the wound-edges. D Representative images of wound closure after local transfection of miR-125 mimic, or miR-NC mimic. E Relative wound area was calculated. ^*P < 0.05 versus miR-125b mimic in one-way analysis of variance (n = 6)