Fig. 3
From: Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment
The biodistribution and therapeutic effect of hNPs in E.G7-OVA tumor-bearing mice. A IVIS images of mice at selected time-points after intravenous injections of cy7-hNPs or free Cy7. B The fluorescence images of organs and tumors collected from mice at 48 h post injection and C quantified mean fluorescence intensity. Tumor growth (D) and animal survival curves (E) of mice treated with PBS, free DOX, free DOX and CpG or hNPs, respectively. F H&E staining images of tumor and heart from mice treated with various formulations. Data represent mean ± SD (n = 5; *P < 0.05, ***P < 0.001)