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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Human neural stem cell-derived extracellular vesicles protect against Parkinson’s disease pathologies

Fig. 1

Antioxidant effect of F3-derived EVs on 6-OHDA-induced oxidative stress in SH-SY5Y cells. SH-SY5Y (human neuroblastoma cell lines used as a model of dopaminergic neurons) exposed to 6-OHDA (450 µM) were treated with HFF-derived EVs (10 or 25 µg) or F3-derived EVs (10 or 25 µg). A Cell viability was measured using the CCK-8 assay 24 h after EV treatment. 6-OHDA-induced SH-SY5Y cell death was significantly reduced by treatment with F3-derived EVs. B Cellular ROS levels were measured using DCFDA. F3-derived EVs significantly reduced 6-OHDA-induced oxidative stress in SH-SY5Y cells. C Caspase 3/7 activity was measured using a luminescence assay. Caspase 3/7 activity was reduced in 6-OHDA-induced SH-SY5Y cells treated with F3-derived EVs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (one-way ANOVA)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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